PH 243A teaches students to construct efficient estimators & obtain robust inference for parameters that utilize data-adaptive estimation strategies (i.e., machine learning). Students perform hands-on implementation of novel estimators using high-dimensional data structures, providing students with a toolbox for analyzing complex longitudinal, observational & randomized control trial data. Students learn & apply the core principles of the Targeted Learning methodology, which generalizes machine learning to any estimand of interest; obtains an optimal estimator of the given estimand, grounded in theory; integrates state-of-the-art ensemble machine learning techniques; & provides formal statistical inference in confidence intervals & testing.

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