This class is designed to introduce students to crucial concepts that underlie the discovery and development of therapeutic modalities. It will cover questions of target discovery and validation; basic properties of therapeutic modalities, such as small molecules, designer proteins, or genome engineering approaches; the design and execution of chemical screens; the medicinal chemistry, pharmacodynamics and -kinetics that is required for drug development; and the steps needed to introduce a new modality into the clinic. Lectures are based on a combination of textbook readings and primary literature and summarized through case studies that highlight critical aspects of drug discovery and development.

Repeat Rules

Course is not repeatable for credit.